Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter with receptors (5-HT receptors) located in cells throughout the body. There are more than a dozen different types of serotonin receptors that fall into several different classes. One class consists of serotonin-activated ion channels and the other receptor classes are G-protein-coupled receptors that associate with different G proteins. The 5-HT7A receptor couples to Gs and activates adenylyl cyclase, while the 5-HT2B receptor couples to G, and activates phospholipase C. The diversity of receptor types has led pharmacologists to search for drugs that will bind to and modulate just a single receptor class in order to limit systemic side effects (see 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials). Place into bins the downstream effects predicted for a drug that exclusively activates the 5-HT7A receptor versus a drug that exclusively activates the 5-HT2B receptor. Items (5 items) (Drag and drop into the appropriate area below) Cytosolic calcium increase PKC activation PKA activation CAMP production IP 3 production Receptor subtype 5-HT7A 5-HT2B

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14-07-2022
Biology

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Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter with receptors (5-HT receptors) located in cells throughout the body. There are more than a dozen different types of serotonin receptors that fall into several different classes. One class consists of serotonin-activated ion channels and the other receptor classes are G-protein-coupled receptors that associate with different G proteins. The 5-HT7A receptor couples to Gs and activates adenylyl cyclase, while the 5-HT2B receptor couples to G, and activates phospholipase C. The diversity of receptor types has led pharmacologists to search for drugs that will bind to and modulate just a single receptor class in order to limit systemic side effects (see 5-Hydroxytryptamine Receptor Subtypes and their Modulators with Therapeutic Potentials). Place into bins the downstream effects predicted for a drug that exclusively activates the 5-HT7A receptor versus a drug that exclusively activates the 5-HT2B receptor. Items (5 items) (Drag and drop into the appropriate area below) Cytosolic calcium increase PKC activation PKA activation CAMP production IP 3 production Receptor subtype 5-HT7A 5-HT2B

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sakshigupta4990 sakshigupta4990 · Answer 1 · 2022-07-19T07:53:25+02:00

The monoamine neurotransmitter 5-hydroxytryptamine, or serotonin, is derived from tryptophan and is synthesized both centrally and systemically.

14 structurally and functionally distinct receptor subtypes have been identified for serotonin, each mediating the action of neurotransmitters via a series of downstream signaling molecules and effectors.

Although most commonly described for its role in the pathogenesis of neuropsychiatric and mood disorders, serotonin is involved in many basic physiological processes including apoptosis, mitochondrial biosynthesis, cell proliferation, and migration. increase. Its role as a neurotransmitter is also manifested in pathogenic conditions ranging from anorexia nervosa to cancer.

This requires an understanding of the signaling mechanisms underlying the serotonergic system, which has led to the creation of an integrated pathway map that provides resources for future biomedical research in this pathway.

Using a rigorous set of NetPath annotation criteria, we manually curated the molecular responses associated with serotonin and its receptors from the published literature. Response categories included molecular association, activation/inhibition, post-translational modification, transport, and gene regulation at the transcriptional and translational levels.

For more information on serotonin (5-hydroxytryptamine, 5-HT), see

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