The event that established the U.S. as a world leader in politics and economics was the Second World War.
Thanks to U.S. actions and victory in WWII, it became the world's leader in politics, economics, and in the military.
This was largely because the U.S. was not largely devastated by the war which was fought away from U.S. shores. It allowed the U.S. to produce goods on a massive scale, and then export its political ideals to other nations.
Find out more on the effect of WWII on the U.S. at https://brainly.com/question/14572632.
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