Respuesta :
Iron released from hemoglobin is transported through the blood by transferrin to the bone marrow.
Transport of Iron
The cellular iron homeostasis is controlled by the iron and heme transport proteins. They work with chaperones, ferrireductases, and ferroxidases which guide the movement of iron within and in & out of the cells. In the blood, the ion released from the hemoglobin molecule is bound to the transport protein transferrin which carries the iron into the bone marrow. Inside the bone marrow, the iron is delivered to the precursors of RBCs, the erythrocyte progenitor cells. Inside the bone marrow, the heme units in the EPC take up the iron to which oxygen will bind as they become mature RBCs. The flow of iron in the blood plasma is controlled by the protein hepcidin whose production is positively influenced by transferrin in the plasma. In the case of damaged RBCs, they are processed by the macrophages of the spleen, liver, and bone marrow which releases the iron molecule.
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