The switch from mitosis to meiosis in spermatogenesis is regulated by Follicle-stimulating hormone (FSH) levels of Luteinizing hormone (LH) and this is induced by Glial cell line-derived neurotrophic factor (GDNF).
How does FSH, LH and GDNF help in spermatogenesis?
- The development and maintenance of spermatogenesis is dependent on the pituitary gonadotropins; FSH and LH.
- FSH works on Sertoli cells and LH on Leydig cells through their receptors FSHR and LHR respectively.
- Self-renewal and differentiation of the spermatogonial stem cells (SSCs) is regulated by soluble factors produced by the somatic Sertoli cells. One of these is glial cell line–derived neurotrophic factor (GDNF).
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