Mast cells are similar to basophils in that they contain granules that release histamine to mediate the inflammatory response.
- The basophil, another type of white blood cell, and the mast cell are remarkably similar in both look and function.
- Although tissue-resident basophils were long assumed to be mast cells, it has been established that the two cells do not share the same hematopoietic ancestry.
- Mast cells and basophil granulocytes, a type of white blood cell found in blood, are highly similar.
- They are both granular cells that contain the anticoagulant heparin as well as histamine.
- The mast cell nucleus is spherical, whereas the basophil nucleus is lobated, indicating a difference between their nuclei.
- Histamine and other vasoactive chemicals are released by mast cells, resulting in urticaria (hives).
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