The intrinsic pathway gets triggered by the activation of clotting factor XII in hemostasis.
We do not fully understand the precise function of factor XII in the clotting process or any extra effects it may have on the body. Factor XII may be involved in tissue repair and blood vessel development in addition to the clotting process (angiogenesis).
The intrinsic pathway is the longer pathway of secondary hemostasis. It begins with the activation of Factor XII (a zymogen, inactivated serine protease) which becomes Factor XIIA (activated serine protease) after exposure to endothelial collagen.
In the vascular system, trauma activates the intrinsic pathway, which is also triggered by platelets, exposed endothelium, chemicals, or collagen. Although slower than the extrinsic pathway, this one is more crucial.
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