Answer:
Oxygen in the blood is required for function of neurons to fire constantly and be in action to transmit information.
Lack of oxygen causes disruption of mitochondrial respiration in motor neurons, disruption of mitochondrial activity, mitochondrial ATP synthesis, defective mitochondrial transport, imbalance in mitochondrial potential ultimately causing atrophy of macular motor neurons in action organs as legs and hands.
This leads to loss of activity of these motor neurons and message passing activity to motor organs eventually. This leads to decrease in functioning or atrophy of motor organs.
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