Diagnostic reagents useful for detecting antigen by the COAGGLUTINATION reaction may be prepared by binding antibody to killed staphylococcal cells via the Fc receptor of staphylococcal protein A. The class of antibody bound by this protein is IgG.
- IgG antibodies are monomers and do not agglutinate immediately (termed non-agglutinating antibodies).
- IgG antibodies are powerful molecules that have the special capacity to connect foreign particles to innate immune cells.
- IgG antibodies attach to cellular Fc receptors with a low affinity while recognizing antigens with a high affinity.
- Immune complexes are formed during these encounters, producing high-avidity interactions.
- Although numerous factors, including the IgG isotype and the makeup of the glycan on the IgG antibody, can affect the Fc receptor binding by IgG antibodies, the effector actions induced by IgG antibodies are strongly dependent on the kind of Fc receptor that is bound.
learn more about antibody here: https://brainly.com/question/15382995
#SPJ4
