The addition of acetyl groups to histones leads to a weaker association of DNA in nucleosomes because they help to condense it into chromatin.
Histones are a family of basic proteins that associate with DNA in the nucleus and help to condense it into chromatin. Nuclear DNA does not appear on free linear strands; it is highly condensed and involves histones to fit inside the nucleus and participate in the formation of chromosomes.
Each chromosome is made up of a single molecule of double-stranded DNA wrapped around histones, the nucleosome. This fiber rewinds into a second level of compression, known as the solenoid. Most of the time, cells keep the DNA compacted in the selenoid loops attached to the chromosomal backbone.
Whit this information, we can conclude that the addition of acetyl groups to histones leads to a weaker association of DNA in nucleosomes because they help to condense it into chromatin.
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