The Opium Wars, the Treaty of Nanjing, and other unequal treaties opened China to unfair trade and treatment from other countries, e.g. the U.S. and France.
The unequal treaties between China and other nations were treaties made between China and western nations, which benefitted the western nations without any benefit to China.
In these treaties and agreements, China conceded many of its territorial and sovereignty rights, leading to frustration with the Qing Dynasty and its overthrow.
Thus, the Opium Wars, the Treaty of Nanjing, and other unequal treaties opened China to unfair trade and treatment from other countries, e.g. the U.S. and France.
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