Leaving out a base during the process of replication is quite dangerous because this may result in a non-functional protein.
When a base is left out during replication and the mRNA generated is used to synthesize protein, the codons will be incomplete and will result in an incomplete or non-functional protein.
Codons are in a base of 3. Thus, leaving out a base means that an entire codon has been rendered useless. This also means that the amino acids of the protein synthesized will be incomplete.
This either results in a totally different or non-functional protein.
More on mutation can be found here: https://brainly.com/question/17106056