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Ozone layer depletion increases the amount of UVB that reaches the Earth's surface. Laboratory and epidemiological studies demonstrate that UVB causes non-melanoma skin cancer and plays a major role in malignant melanoma development.

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Ozone depletion can cause increased amounts of UV radiation to reach the Earth which can lead to more cases of skin cancer, cataracts, and impaired immune systems. Too much exposure to UV is believed to be contributing to the increase in melanoma, the most fatal of all skin cancers