Answer:
Victor's downfall wasn't his own intelligence, it was how he let it consume him. He watched Justine get hanged for a crime he knew she didn't commit, and nearly got thrown in jail for Henry's homicide as well. He knew these things, and how dangerous it was to leave the creature all alone, and yet he didn't try and be a good father. If there was some semblance of parenthood in the creatures life (namely if Victor didn't run away at the sight of his creation), then all the homicides likely would have never happened. Is all of this Victor's fault though? On some level, absolutely, since through his own curiosity suffering struck the Frankenstein name, but on another, not really. He was just a kid by the time The Creature came around, and with the yellow eyes he may have thought his creation had come down with an illness like Jaundice. He didn't know how to care for a 7ft tall man, or even if he could, and he hadn't thought of the implications. So, no, his downfall wasn't intelligence, it was ignorance.
Although powerful, knowledge can strike hard, and this is shown in Frankenstein. With knowledge, he created this being who ended up responsible for at least four people's lives lost. If Victor wasn't so dead-set on just creating, and thought about the consequences of creating life, things wouldn't have been as destructive. Even through his time at Ingolstadt with all the studying, he still didn't know how dangerous things could be. That's how things went wrong, he just didn't know or believe it could've gone this way. He didn't know he'd have to either be a father or let the world burn.
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