The most highly sensitive time within the developing embryo for the risk of malformation related to environmental teratogens is cleft palate at 8 weeks gestation. It is an opening in the roof of the mouth.
A teratogen is any substance and/or physical agent that may cause an irreversible abnormality in the structure of the developing embryo or fetus (e.g., classical pesticides such as DDT).
Cleft palate is a malformation mainly caused by mutagenic agents (teratogens) during pregnancy, which affects approximately one (1) of 650 births.
A cleft palate is a malformation that occurs when the two plates of the skull that form the roof of the mouth cannot be completely joined.
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