The steps of tissue repair in order from start to finish are 1, 3, 2, 4.
The method of tissue repair follows some steps below especially when the damaged tissue are in close apposition.
These steps in order from start to finish include:
- Bleeding into the cut: This is the homeostasis stage. As the wound bleeds, the aim of this stage is to stop the bleeding by activation of emergency repair system, the blood clotting system.
- Scab formation; macrophages become active: This is the inflammatory stage. Phagocytes such as the macrophages begin to remove the dry blood clot called scabs and cell debris.
- Formation of granulation tissue and fibroblastic phase of repair: This stage is called the proliferation stage. Granulation tissue which contains new capillary buds, phagocytes and fibroblasts, develops. Fibroblasts continues to secrete collagen fibres for the tissue restoration.
- Epithelial regeneration; fibrosis; remodeling phase: This is the maturation stage. Here, the granulation tissue is replaced by fibrous scar tissue and rearrangement of the collagen fibres occurs, increasing the strength of the wound.
Therefore, the steps of tissue repair in order from start to finish are 1, 3, 2, 4.
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