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Three-parent baby, human offspring produced from the genetic material of one man and two women through the use of assisted reproductive technologies, specifically mitochondrial manipulation (or replacement) technologies and three-person in vitro fertilization (IVF). In general, the reproductive technologies used to produce three-parent babies focus on replacing or otherwise reducing the effects of mutations that occur in the DNA of cellular organelles known as mitochondria, which reside in the cell cytoplasm. The various approaches could help women to overcome infertility and could prevent the transmission to their offspring of potentially debilitating mitochondrial diseases.