Cotton, timber and tobacco industries in North Carolina were most affected by railroad expansion. Options B, E, and F are correct.
The railroad helped international trade by carrying western food crops and raw materials to East Coast markets, and factory-made goods from an East Coast location to the West Coast.
Railroad expansion had the greatest impact on North Carolina's cotton, timber, and tobacco industries, because it increases the trading of that materials.
Therefore, option B, E, and F are correct.
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