The recombination frequency between linked genes A and B is 40%, between B and C is 20%, between C and D is 10%, between C and A is 20%, and between D and B is 10%. What is the sequence of the genes on the chromosome?

The linked genes A and B have a greater frequency of recombination (40%) and therefore they are found furthest away on the chromosome. Conversely, the smaller distance is between D and B, which exhibit a lower frequency of recombination (10%), while C is localized at the same physical distance of both A and B (20%), so the physical map is ACDB.

Physical map:

A--------C-----D-----B

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throwdolbeau throwdolbeau · Answer 2 · 2022-01-13T12:51:58+01:00

The sequence of the genes on the chromosome is ACDB (or BDCA).

The linked genes A and B have a greater frequency of recombination (40%) and therefore they are found furthest away on the chromosome.
Conversely, the smaller distance is between D and B, which exhibit a lower frequency of recombination (10%), while C is localized at the same physical distance of both A and B (20%), so the physical map is ACDB.

Physical map:

A physical map of a chromosome or a genome that shows the physical locations of genes and other DNA sequences of interest.

It can be represented as:

A--------C-----D-----B

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