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Perhaps the most amazing thing about mitosis is its precision, a feature that has intrigued biologists since Walther Flemming first described chromosomes in the late 1800s (Paweletz, 2001). Although Flemming was able to correctly deduce the sequence of events in mitosis, this sequence could not be experimentally verified for several decades, until advances in light microscopy made it possible to observe chromosome movements in living cells. Researchers now know that mitosis is a highly regulated process involving hundreds of different cellular proteins. The dynamic nature of mitosis is best appreciated when this process is viewed in living cells.
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