What if researchers followed a similar method used in this activity to calculate the correlation coefficients for the gene expression patterns of every patient with osteosarcoma and they found that all patients fell into two categories of gene expression patterns? What would this tell you about the single disease we call osteosarcoma? How might this information affect osteosarcoma cancer patient diagnosis and treatment in the future?

Cancer can be defined as a group of genetic diseases that are characterized by uncontrolled/inappropriate cell growth. In general, cancer pathways are associated with abnormal expression of signaling components that disrupt the regulatory networks capable of controlling cell function, thereby cancerous cells can inhibit programmed death cell (apoptosis). Osteosarcoma is one type of cancer disease that starts in the bones, i.e., this disease may be triggered by overactivity of bone cells. Additionally, it is important to note that different immune-related genes were recently found to be dysregulated in osteosarcoma. For example, differentially expressed immune-related genes involved in PI3K/AKT, MAPK and JAK-STAT signaling pathways have shown prognostic value in this disease.

kamakshiruhela11 kamakshiruhela11 · Answer 2 · 2022-04-07T11:11:14+02:00

Abnormal gene expression patterns can lead to osteosarcoma, different signalling pathways are involved in osteosarcoma, and differentially expressed genes might be promising biomarkers for the early detection of osteosarcoma.

What is the cause of osteosarcoma?

Most osteosarcomas are not caused by inherited gene modifications, but instead are the effect of gene changes acquired during the individual lifetime.

Sometimes these gene modifications are caused by radiation therapy used to treat another form of cancer because radiation can harm the DNA inside cells.

Thus, these are the following reasons.

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