Answer:
The colonists at Jamestown were not particularly skilled farmers. Many of them were professionals: religious people who wanted to escape religious persecution in England.
They hoped that they would engage in active trade with the Native Americans.
This hope proved to be untrue. When the colonists arrived, the region sorrounding Jamestown was experiencing a serious drought, and the Native Americans were short of food. They did not have enough spare produce to trade with the colonists, and the colonists represented more competition for the limited resources.
Most colonies perished either form starvation or disease, making the Jamestown colony a failed attempt to colonize the area.