Which of the following best describes how ACh changes the ion permeability of the sarcolemma?
A) ACh activates acetylcholinesterase.
B) ACh entry into the axon terminal causes neurotransmitter release.
C) ACh binds to receptors in the junctional folds.
D) ACh entry into the muscle fiber causes Ca2+ to be released by the sarcoplasmic reticulum.

The statement 'ACh binds to receptors in the junctional folds' best describes how ACh changes the ion permeability of the sarcolemma (Option C).

The sarcolemma is the plasma membrane of the muscle cells.

Moreover, acetylcholine (ACh) is a neurotransmitter that is released by motor neurons during muscle contraction.

After release, ACh binds to specific (nicotinic) receptors in the sarcolemma at the neuromuscular junctions (i.e., junctional folds).

These receptors are also called chemical-gated and/or ligand-gated channels because they are known to modify the ion permeability of the sarcolemma.

In conclusion, the statement 'ACh binds to receptors in the junctional folds' best describes how ACh changes the ion permeability of the sarcolemma (Option C).

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