Answer:
No.If a lizard is tremendous you could not hold it in one hand.
Explanation:
The word tremendous is a synonym to words like humongous, gigantic, and other words that mean "very large".
A tremendous lizard could not be held in one hand because it is a "gigantic" reptile.
Therefor, the answer would be: no, a tremendous lizard would not be able to be held in one hand.