Answer: In Tay-Sachs disease, lysosomes are affected.
Explanation: Tay-Sachs disease is a genetic disorder that destroys neurons in the nervous system (brain and spinal cord). Though rare, affected infants lose motor skills like sitting and crawling. Also, signs and symptoms are usually milder according to age as it can appear in childhood, adolescence or adulthood.
Tay-Sachs disease is caused by mutation in the HEXA gene which is responsible for making part of an enzyme called beta-hexosaminidase A. This enzyme plays an important role in the brain and spinal cord and is located in the lysosomes.