Answer:
D) intracellular accumulations.
Explanation:
When the normal metabolism changes in the cell changes and becomes abnormal it leads to the accumulation of the products in the cell.
The accumulated substances may be normal cellular substances like the proteins, lipids or any other biomolecule or it could be external constituents like from the pathogen or the result of the pathogen.
These accumulated substances change the normal physiology of the cell and lead to faulty metabolism which produces responses like the reabsorption or proteins in the renal tubules and many other which causes certain disorders.
Thus, Option-D is the correct answer.
