Respuesta :
Answer:
E1: Pyruvate dehydrogenase, TPP, oxidative decarboxylation reaction
E2: Dihydrolipoyl transacetylase, Lipoamide and Co-enzyme A, transacetylation reaction.
E3: Dihydrolipoyl dehydrogenase, FAD and NAD+, oxidation reaction
Explanation:
Pyruvate dehydrogenase is a multi-enzyme complex with 5 co-enzymes and 3 apo-enzymes:
Pyruvate dehydrogenase (E1) , which uses thiamine pyrophosphate (TPP) as as co-enzymes to catalyze oxidative decarboxylation of pyruvate to hydroxyethyl-TPP.
Dihydrolipoyl transacetylase (E2): which uses lipoamide and coenzyme A as co-enzymes to catalyse the transacetylation from TPP to Lipoamide to form acetyl lipoamide.
Dihydrolipoyl dehydrogenase (E3) which uses FAD and NAD+ as co-enzymes to catalyze the oxidation of lipoamide
E1 is pyruvate dehydrogenase and catalyzes oxidative decarboxylation, whereas E2 is dihydrolipoyl trans-acetylase and catalyzes the acetyl transfer to coenzyme A (CoA).
What is pyruvate dehydrogenase?
The pyruvate dehydrogenase is an enzyme, which is part of a multienzyme complex involved in catalyzing the decarboxylation of pyruvate to CoA.
- E2 is a well-known dihydrolipoyl trans-acetylase enzyme that catalyzes the acetyl transfer to coenzyme A (CoA).
- Finally, E3 is the dihydrolipoyl dehydrogenase enzyme and catalyzes the oxidation reaction.
In conclusion, E1 is pyruvate dehydrogenase and catalyzes oxidative decarboxylation, whereas E2 is dihydrolipoyl trans-acetylase and catalyzes the acetyl transfer to coenzyme A (CoA).
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