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Which statement regarding heterotrimeric G proteins in a resting state is true?
A. GTP is bound to the α subunit in a complex with both the β and γ subunits.
B. GDP is bound to the α subunit in a complex with both the β and γ subunits.
C. The proteins are in a complex with G protein-coupled receptors.
D. GDP is bound to the β subunit in a complex with both the α and γ subunits.

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Answer:

B) GDP is bound to the alpha subunit in a complex with both the beta and gamma subunits

Explanation:

Heterotrimeric G proteins consist of three (3) distinct subunits, alpha (α), beta (β) and gamma (γ). These proteins couple the activation of diverse types of plasma membrane receptor to a variety of intracellular processes. Basically, most types of neurotransmitter and peptide hormone receptor, as well as many cytokine and chemokine receptors, fall into a superfamily of structurally related molecules, termed G protein-coupled receptors.