Answer:
C and D.
Explanation:
The settlers built a fort in Powhatan Indians' territory, starting their complicated relationship.
After Captain Newport's departure, the settlers contracted many diseases due to the lack of food and proper drinking water.
The Chief of Powhatan Indians sent food to help the settlers. However, during a drought, they demanded more food from the Indians and their troubled relationship broke down.
In winter 1609/10 - which is known as "Starving Time" - they were so afraid to leave the fort, they started to eat anything they could find, including fellow settlers.