Answer:
1. Irreversible Inhibition-Inhibitor may permanently modify an enzyme
2. Irreversible inhibition- Tamiflu, a transition state analog, reversibly binds to neuraminindase
3. Competitive Inhibition-Inhibitor binds reversibly to an enzyme's active
4.Irreversible inhibition-Inhibitor binds to an enzyme at a site other than active site
5. Mixed inhibition-The Al3+ ion binds to acetylcholinesterase or to the acetylcholinesterase- substrate complex
6. Irreversible inhibition-DIPF permanently modifies the hydroxyl group of a Serine residue at the active site
Explanation:
- An enzyme is a biological catalyst that catalysis chemical reactions.
- Enzyme activity is influenced by several factors which include enzyme inhibitors, temperature, and pH among others.
- Enzyme inhibitors are molecules that bind to the enzyme thus interfering with enzyme activity and preventing the binding of substrate to the enzyme.
- Inhibitors may either irreversibly or reversibly bind the enzymes.
- Competitive inhibitors compete with substrates for the active sites while non-competitive inhibitors bind irreversibly to other sites on the enzyme other than the active site.
- Tamiflu is an example of a competitive inhibitor.
- DIPF is an example of a non-competitive inhibitor as it binds the enzyme permanently.
