Answer:
c. the degradation of cyclin is the correct answer.
Explanation:
The decline of MPF activity at the end of mitosis is due to the degradation of cyclin.
The MPF stands for maturation promoting factor is an enzyme promotes the passage into M phase from the growth phase (G2 )
During the mitosis process the enzyme which breaks the cyclin gets activated and due to this level of cyclin gets decrease.
The decrease in the levels of the cyclin leads to a decline in the levels of MPF at the end of mitosis.
MPF is composed of cyclin and kinase. It lets the cell go from G2 stage to M stage. When the cell is going to anaphase, MPF inactivates. The decline of MPF activity at the end of mitosis is due to the degradation of cyclin. Option (C).
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Many molecules regulate the cell cycle during the different stages of the mitosis process to make it possible.
There are too many factors interacting, activating, and deactivating to pass from one stage to another.
Cyclins are cell cycle regulator proteins that control the cell during the process of division. Different types of cyclins act on a different stages.
When the cell is going through one of the stages, the only cyclin in high levels is the one that is regulating that part of the cycle.
Once that stage is over, that cyclin concentration decreases, and the following one increases.
Kinases, Cdk, are enzymes that depend on cyclins and that remain inactive until cyclins are present.
The enzyme becomes functional when the cyclin binds it. Then, the kinase can accomplish its functions.
When the cyclin and the kinase are together, they compose the Maturation Promotor Factor, MPF.
MPF is composed of cyclin and kinase. MPF is in charge of letting the cell go from the G2 stage to the M stage.
The inactivation of MPF is due to the degradation of cyclin. As cyclin is destroyed, the MPF gets inactive.
Steps:
1) During the whole cell cycle, cyclin M remains at low levels.
2) When the cell is ready to pass from G2 to M phases, cyclin M increases its concentration and binds Cdk.
3) Together, these proteins compose the MPF that makes this transition possible.
4) Once the cell is in the M stage, MPF needs to decrease.
5) The factor autoregulates by activating another complex. The anaphase-promoting complex/cyclosome, APC/C.
6) When the cell is ready to go from metaphase to anaphase, the APC/C complex begins the cyclins M elimination process. The complex also activates separase to separate chromatid sisters while destroying cyclins M.
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