Which sentence is the most appropriate introduction for a caption about Vincent van Gogh’s “Portrait of Dr. Gachet”?

There are many details in this painting by Vincent van Gogh that show the subject is down and out.

This painting by Vincent van Gogh, titled “Portrait of Dr. Gachet,” illustrates feelings of gloom.

This painting, “Portrait of Dr. Gachet” by Vincent van Gogh, is a great image of a man who is bored and upset.

The artist of “Portrait of Dr. Gachet” uses color, texture, and expression to depict the mood.