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Which of the following statements supports the one gene-one enzyme hypothesis?

A) A mutation in a single gene can result in a defective protein.
B) Sickle-cell anemia results in normal hemoglobin.
C) Multiple antibody genes can code for different related proteins, depending on the splicing that takes place post-transcriptionally.
D) Alkaptonuria results when individuals lack multiple enzymes involved in the catalysis of homogentisic acid.

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Answer:

A) A mutation in a single gene can result in a defective protein.

Explanation:

This hypothesis states that one gene codes for one protein-enzyme, so consequently, if mutation occurs in that gene, the enzyme will not work properly. This hypothesis was very important for the fundamental discoveries of molecular biology, but it is oversimplified meaning that relationship between genes and proteins is much more complex.

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