As a scientist employed by the FDA, you've been asked to sit on a panel to evaluate a pharmaceutical company's application for approval of a new weight loss drug called Fat Away. The company has submitted a report summarizing the results of their animal and human testing. In the report, it was noted that Fat Away works by affecting the electron transport chain. It decreases the synthesis of ATP by making the mitochondrial membrane permeable to H+, which allows H+ to leak from the intermembrane space to the mitochondrial matrix. This effect leads to weight loss.The method of weight loss described for Fat Away shows that the drug is acting as a metabolic

Metabolic uncouplers are chemicals/molecules that have ability to shuttle H+ across the membrane disrupting the proton motive force necessary for the generation of ATP. As a consequence the ATP synthesis is reduced and anabolism is slowed down. These processes also known as metabolic uncoupling lead to the reduction in biomass yield (weight loss).

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