The release of neurotransmitters molecules are caused by an action potential reaching the end of an axon.
An action potential is a sort of electrical impulse. These electrical impulses are generated in order to polarize or depolarize the membrane surrounding cells. When this polarization happens to the membrane of a neuron, neurotransmitters may be released.
Therefore, we can confirm that the release of neurotransmitter molecules are caused by an action potential reaching the end of an axon.
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