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cognitive and physical deterioration, frequently resulting in early death A. cystic fibrosis B. Down syndrome C. fragile X syndrome D. Huntington’s disease E. phenylketonuria F. sickle cell anemia G. spina bifida H. Tay-Sachs disease

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kierrall
I believe the answer is Tay-sachs, cystic fibrosis deteriorates the lungs but not the mind which would be the cognitive part of your question