Which of the following statements about enzyme mechanism reaction steps are true (select all that apply)?
O On a reaction coordinate diagram, a reversible step is indicated by reactant and product at similar energy
O Irreversible steps are important in enzyme mechanisms to help ensure enzymes catalyze reactions in the desired direction
O Substrate binding is usually an irreversible step
O Irreversible steps of a reaction mechanism are always very slow
O To determine if a step is reversible or irreversible, it is necessary to know the activation energy of the step