A client with cancer develops pancytopenia during the course of chemotherapy. The client asks the nurse why this has occurred. The nurse explains that:
1. Steroid hormones have a depressant effect on the spleen and bone marrow
2. Noncancerous cells also are susceptible to the effects of chemotherapeutic drugs
3. Lymph node activity is depressed by radiation therapy used before chemotherapy
4. Dehydration caused by nausea, vomiting, and diarrhea results in hemoconcentration