A 6-month-old arrives with swelling to the left thigh. Caregivers deny any traumatic event. Assessment findings include a patient who is active and alert, in the 10th percentile for length, and has blue-grey sclera. Radiographs reveal a midshaft fracture of the left femur. Which of the following is the most likely cause?
1) Osteomyelitis
2) Physical maltreatment
3) Ehlers-Danlos syndrome
4) Osteogenesis imperfecta