Learning Questions: - 3- Milenko and Ogilvie (1973) demonstrated that theophylline followed a two-compartment pharmacokinetic model in human subjects. After administering a single intravenous dose (5.6 mg/kg) in nine normal volunteers, blood samples were withdrawn over a 7-hour period and assayed for intact drug. The results are tabulated below. Using the method of residuals, calculate the values for intercepts A and B and slopes a, b, k12, and k21. What is the plasma level of the drug 3 hours after the dose?