How does the CRISPR/Cas9 system generate small indels associated with the DNA target sequence?
A) Cas9 nuclease activities generate a blunt double-stranded DNA break just upstream of the protospacer adjacent motif (PAM).
B) Cas9 introduces single-stranded breaks in the DNA.
C) CRISPR RNA (crRNA) forms a complex with Cas9 to bind to the target DNA sequence.
D) The CRISPR/Cas9 system induces point mutations at the target site.