What is the cause of thrombotic thrombocytopenia purpura?
1) Autoantibody-mediated inhibition of the enzyme ADAMTS13
2) Increase in circulating multimers of vWF increases platelet adhesion to areas of endothelial injury
3) Formation of small platelet clots called thrombi
4) Decrease in the number of overall circulating platelets
5) Life-threatening bleeds