Which of the following is not true for patients with heart failure?
1) There is a decline of hepatic clearance for drugs with moderate - high hepatic extraction ratio
2) Increase Bioavailability of drugs
3) The volume of distribution for some drugs decreases in patients with heat failure
4) There is change in drug pharmacokinetic due to change in renal blood flow
5) Half-life of drug is difficult to predict in patients with renal failure