Glycogen phosphorylase (GP) is a soluble protein (it is not a membrane protein). It is a key enzyme in the hydrolysis of glycogen and is normally localized to lysosomes. An individual has a mutation in the signal peptide (rough ER zip code) of GP (all of the GP made by this individual has a defective signal peptide). Which of the following would occur as a result of this mutation?
1) GP would not be able to bind to glycogen
2) GP would not be able to enter the lysosomes
3) GP would not be able to hydrolyze glycogen
4) GP would not be able to be synthesized