NSAID's (first-line treatment for pain, first step on WHO pain ladder)

Work by inhibiting the _________________________ or (_______) ______________, which prevents the production of __________________________ and _______________________. These paracrine molecules cause ______,, and ______________, so blocking their production results in _______________________, ___________________, and _______________________ effects

There are 2 different COX enzymes COX1 and COX2. COX1 protects the stomach from its own acidic environment and COX2 causes inflammation and pain. Remember this by Someone with stomach pain may 1 want food but it's 2 painful. Aspirin, ibuprofen, and naproxen inhibit COX1 and COX2 leading to positive effects of NSAIDS but leading to stomach upset and life-threatening ulceration or bleeding.

Scientists later came out with selective NSAID's that only inhibited COX2 but they brought problems of their own like MI and stroke. Selectcoxib is selective for COX2.

NSAID's can damage both the ______________ and the ________________ __________.
a) Cyclooxygenase; prostaglandins; leukotrienes; inflammation, pain; stomach, cardiovascular system
b) Nitric oxide synthase; prostacyclin; thromboxane; vasoconstriction, vasodilation; stomach, liver
c) Cyclooxygenase; prostaglandins; leukotrienes; vasodilation, vasoconstriction; liver, kidneys
d) Nitric oxide synthase; prostacyclin; thromboxane; inflammation, pain; liver, kidneys