With respect to finding and appraising the evidence, please select all of the following statements which are true.
Select one or more:
a.
A bias of particular concern for meta-analysis studies is publication bias
b.
If a finding from an RCT (e.g. reporting the efficacy of a treatment) is reported to be 'statistical significant', this can be interpreted to mean that the clinical importance of the finding is clearly clinically meaningful.
c.
Prospective case-control studies have less risk of bias compared to retrospective case-control studies, particularly when answering questions about risk factors for rare outcomes.
d.
With respect to a hypothetical RCT is comparing Treatment A vs. Treatment B - if a participant is randomised to Treatment A, but is accidentally given Treatment B, in an intention-to-treat (ITT) analysis this participant would be included in the Treatment A group.
e.
Systematic reviews can only include randomised controlled trials
f.
Randomised controlled trials are the most appropriate study design for research questions about the frequency of events.
g.
Non-inferiority trials are undertaken to assess whether a treatment is superior compared to no treatment.
h.
Systematic bias refers to a deviation from the truth in a particular direction (e.g. over or under estimation of the 'truth')
i.
The Database of Abstracts of Reviews of Effects (DARE) is an good way to identify systematic reviews because it contains an concise expert commentary informing the quality of the systematic review.
j.
Randomised allocation of participants in RCTs ensures that treatment groups are equivalent in terms of known confounders, but this does not ensure treatment groups are equivalent in terms of unknown confounders.
k.
Systematic reviews are the best source of evidence on treatment effectiveness because all systematic reviews are of high quality
l.
Cohort studies are particularly well suited for assessing research questions about treatment effectiveness