Which line best helps develop the central idea that the plague was a very deadly disease?

“Elizabethans do not understand infection and contagion as we do.”
“In 1565 the people of Bristol count up the plague victims for that year and arrive at the figure of 2,070 . . .”
“This last epidemic originates in Portugal and is brought to Devon by mariners.”
“It is ironic that the great naval ships that deliver the English from the Spanish threat bring another danger . . .